Article
Structural insights into the interaction between adenovirus C5 hexon and human lactoferrin.
Journal of virology - 19 Mar 2024
Dhillon Arun, Persson B David, Volkov Alexander N, Sülzen Hagen, Kádek Alan, Pompach Petr, Kereïche Sami, Lepšík Martin, Danskog Katarina, Uetrecht Charlotte, Arnberg Niklas, Zoll Sebastian
Abstract excerpt
Adenovirus (AdV) infection of the respiratory epithelium is common but poorly understood. Human AdV species C types, such as HAdV-C5, utilize the Coxsackie-adenovirus receptor (CAR) for attachment and subsequently integrins for entry. CAR and integrins are however located deep within the tight junctions in the mucosa where they would not be easily accessible. Recently, a model for CAR-independent AdV entry was...
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