Article

TLR4-mediated neuroimmune signalling drives proprioceptive neuron degeneration in Friedreich ataxia

2026-04-30

Abstract excerpt

Friedreich ataxia (FA) is one of the most common inherited autosomal recessive neurodegenerative disorder, caused by a GAA repeat expansion in the FXN gene, leading to frataxin deficiency and progressive sensory and spinocerebellar ataxia. FA is characterized by selective vulnerability of proprioceptive sensory neurons (pSNs) in the dorsal root ganglia (DRG), which are major contributors to sensory ataxia. Despit...

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Literature Corpus work: 8e231380-4b25-5bc5-b2f1-5ccc151d4b5c
DOI: 10.64898/2026.04.28.721289

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