Article

Alzheimer’s disease-associated P460L mutation in ephrin receptor type A1 (EphA1) leads to dysregulated Rho-GTPase signaling

2021-06-18

Abstract excerpt

<h4>ABSTRACT</h4> Recently, late onset AD (LOAD) genome-wide association studies identified EphA1, a member of receptor tyrosine kinase family (RTK) as a disease associated loci. In the follow-up study where 3 independent LOAD cohorts were performed, a P460L coding mutation in EphA1 loci showed a significant association with LOAD. However, the role of EphA1 and P460L mutant EphA1 in AD is not fully understood. We...

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Literature Corpus work: 8dfe93df-2f66-55e6-b81a-6cf95781da18
DOI: 10.1101/2021.06.17.448790

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