Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional analysis of deleterious EPHA2 SNPs in lens epithelial cells.

Molecular vision - 1 Jan 2021

Li Dan, Han Xiaoyan, Zhao Zhennan, Lu Yi, Yang Jin

Abstract excerpt

Purpose: Ephrin (Eph) receptor A2 (EPHA2) polymorphism has been associated with age-related cataract (ARC) in different populations worldwide, but the mechanisms by which this polymorphism results in the development of ARC are unclear. Here, we chose four EPHA2 single nucleotide polymorphisms (SNPs; rs35903225, rs145592908, rs137853199, and rs116506614) and studied their function in human lens epithelial cells...

Read the complete abstract on PubMed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Western
Share to Cataract
Share to Epithelial Cells
Share to Lens, Crystalline
Share to Lentivirus
Share to Point Mutation
Share to Real-Time Polymerase Chain Reaction
Share to Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 34220184
PMCID: PMC8219505

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional analysis of deleterious EPHA2 SNPs in lens epithelial cells.PMID 34220184Read ↗

Functional analysis of deleterious EPHA2 SNPs in lens epithelial cells.Semantic proximity Read ↗

Functional non-coding polymorphism in an EPHA2 promoter PAX2 binding site modifies expression and alters the MAPK and AKT pathways.Semantic proximity Read ↗

Biallelic Variants in EPHA2 Identified in Three Large Inbred Families with Early-Onset Cataract.Semantic proximity Read ↗

Germ-line and somatic EPHA2 coding variants in lens aging and cataract.Semantic proximity Read ↗

Mutations of the EPHA2 receptor tyrosine kinase gene cause autosomal dominant congenital cataract.Semantic proximity Read ↗

The EPHA2 gene is associated with cataracts linked to chromosome 1p.Semantic proximity Read ↗

Identification of a novel C-terminal extension mutation in EPHA2 in a family affected with congenital cataract.Semantic proximity Read ↗

Mutations in the EPHA2 gene are a major contributor to inherited cataracts in South-Eastern Australia.Semantic proximity Read ↗

EPHA2 MUTATIONS CONTRIBUTE TO CONGENITAL CATARACT THROUGH DIVERSE MECHANISMS.Semantic proximity Read ↗

Mutational screening of EFNA5 in Chinese age-related cataract patients.Semantic proximity Read ↗

A novel splice donor site mutation in EPHA2 caused congenital cataract in a Chinese family.Semantic proximity Read ↗

EPHA2 Polymorphisms in Estonian Patients with Age-Related Cataract.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.