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High-dimensional proteomics identifies organ injury patterns associated with outcomes in human trauma

13 Feb 2023

Abstract excerpt

INTRODUCTION: Severe traumatic injury with shock can lead to direct and indirect organ injury; however, tissue-specific biomarkers are limited in clinical panels. We used proteomic and metabolomic databases to identify organ injury patterns after severe injury in humans. METHODS: Plasma samples (times 0, 24, and 72 hours after arrival to trauma center) from injured patients enrolled in two randomized prehospital...

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PMID: 36787435
DOI: 10.1097/ta.0000000000003880

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