Article

Metabolic Alterations driven by PFKFB3 upregulation confer Resistance to Trastuzumab in HER2-Positive Breast Cancer

2025-10-10

Abstract excerpt

<h4>Aims</h4> Resistance to anti-HER2 therapies, particularly trastuzumab, remains a major obstacle in the treatment of HER2-positive (HER2+) breast cancer. This study aims to uncover novel mechanisms driving trastuzumab resistance with a focus on the immune component, key mediator of trastuzumab efficacy. <h4>Methods</h4> We developed an isogenic cell line-derived xenograft model to perform transcriptome-wide a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 68a04f75-a923-5538-91c0-06f80dbb9a2c
DOI: 10.1101/2025.10.09.681343

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Metabolic Alterations driven by PFKFB3 upregulation confer Resistance to Trastuzumab in HER2-Positive Breast CancerDOI 10.1101/2025.10.09.681343Read

Lipid Metabolism Reprogramming and Trastuzumab Resistance in Breast Cancer Cell Lines Overexpressing the ERBB2 Membrane ReceptorSemantic proximity Read

Micromapping (µMap) of HER2 Across Human Breast Cancers: Photocatalytic Proximity Labeling Identifies Primary Resistance Mechanisms and Functional InteractorsSemantic proximity Read

Lipid Metabolism Reprogramming Is Associated with Trastuzumab Resistance in ERBB2+ Breast Cancer Cell LinesSemantic proximity Read

HER2 + breast cancers evade anti-HER2 therapy via a switch in driver pathway.Semantic proximity Read

Immunotherapy Implication of Signature-Guided Biomarker Discovery for Trastuzumab-Resistant HER2-Positive Breast CancerSemantic proximity Read

PFKFB4 facilitates palbociclib resistance in oestrogen receptor‐positive breast cancer by enhancing stemnessSemantic proximity Read

Investigation of ITGB3 Heterogeneity to Overcome Trastuzumab Resistance in HER2-Positive Breast CancerSemantic proximity Read

Disrupted Lipid Metabolism, Cytokine Signaling, and Dormancy: Hallmarks of Doxorubicin-Resistant Triple-Negative Breast Cancer ModelsSemantic proximity Read

Unraveling Vulnerabilities in Endocrine Therapy-Resistant HER2+/ER+ Breast CancerSemantic proximity Read

Kinase Plasticity with Vandetanib Treatment Enhances Sensitivity to Tamoxifen in Estrogen Receptor Positive Breast CancerSemantic proximity Read

Resistance to abemaciclib is associated with increased metastatic potential and lysosomal protein deregulation in breast cancer cellsSemantic proximity Read

Concurrent mutations associated with trastuzumab-resistance revealed by single cell sequencing.Semantic proximity Read