Article

Analysis of the mutation dynamics of SARS-CoV-2 reveals the spread history and emergence of RBD mutant with lower ACE2 binding affinity

2020-04-11

Abstract excerpt

<h4>Summary</h4> Monitoring the mutation dynamics of SARS-CoV-2 is critical for the development of effective approaches to contain the pathogen. By analyzing 106 SARS-CoV-2 and 39 SARS genome sequences, we provided direct genetic evidence that SARS-CoV-2 has a much lower mutation rate than SARS. Minimum Evolution phylogeny analysis revealed the putative original status of SARS-CoV-2 and the early-stage spread his...

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Literature Corpus work: 8de5a2e9-8f70-502f-88ed-b306dee0545e
DOI: 10.1101/2020.04.09.034942

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