Article

Chronic ER Stress Disrupts Mitochondrial-Associated ER Membrane Integrity in Corneal Endothelial Cells

2026-01-11

Abstract excerpt

<h4>Purpose</h4> Fuchs’ endothelial corneal dystrophy (FECD) is an age-related degenerative disease of the corneal endothelium cells (CEnCs), affecting 4% of the US population over 40. While Endoplasmic reticulum (ER) and mitochondrial stress have been independently associated with FECD pathogenesis, few studies have examined ER-mitochondrial interactions/ER-mitochondrial contact sites/mitochondria-associated ER...

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Literature Corpus work: 8d86b419-5998-55c3-b907-3ae7d831e0b7
DOI: 10.64898/2026.01.09.698664

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