Article

SETD2 deficiency impairs β-catenin destruction complex to facilitate renal cell carcinoma formation

2020-07-14

Abstract excerpt

Clear cell renal cell carcinoma (ccRCC) is a largely incurable disease that is highly relevant to epigenetic regulation including histone modification and DNA methylation. SET domain–containing 2 (SETD2) is a predominant histone methyltransferase catalyzing the trimethylation of histone H3 Lysine 36 (H3K36me3) and its mutations are highly relevant to clear cell renal cell carcinoma (ccRCC). However, its physiology...

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Literature Corpus work: 8d5d425b-8f11-529d-8d4b-f8388be09f91
DOI: 10.1101/2020.07.13.200220

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