Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Methylome-wide Analysis of Chronic HIV Infection Reveals Five-Year Increase in Biological Age and Epigenetic Targeting of HLA.

Molecular cell - 21 Apr 2016

Gross Andrew M, Jaeger Philipp A, Kreisberg Jason F, Licon Katherine, Jepsen Kristen L, Khosroheidari Mahdieh, Morsey Brenda M, Swindells Susan, Shen Hui, Ng Cherie T, Flagg Ken, Chen Daniel, Zhang Kang, Fox Howard S, Ideker Trey

Abstract excerpt

HIV-infected individuals are living longer on antiretroviral therapy, but many patients display signs that in some ways resemble premature aging. To investigate and quantify the impact of chronic HIV infection on aging, we report a global analysis of the whole-blood DNA methylomes of 137 HIV+ individuals under sustained therapy along with 44 matched HIV- individuals. First, we develop and validate epigenetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Anti-HIV Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD4-CD8 Ratio

Share to Chronic Disease

Share to CpG Islands

Share to DNA Methylation

Share to Epigenesis, Genetic

Share to HLA Antigens

Source

Open in PubMed Open full text

Identifiers

PMID: 27105112
DOI: 10.1016/j.molcel.2016.03.019
PMCID: PMC4995115

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Methylome-wide Analysis of Chronic HIV Infection Reveals Five-Year Increase in Biological Age and Epigenetic Targeting of HLA.PMID 27105112Read ↗

Occurrence of Accelerated Epigenetic Aging and Methylation Disruptions in Human Immunodeficiency Virus Infection Before Antiretroviral TherapySemantic proximity Read ↗

HIV-1 Infection Accelerates Age According to the Epigenetic ClockSemantic proximity Read ↗

Epigenome-wide epidemiologic studies of human immunodeficiency virus infection, treatment, and disease progressionSemantic proximity Read ↗

Identification of HIV infection-related DNA methylation sites and advanced epigenetic aging in HIV-positive, treatment-naive U.S. veteransSemantic proximity Read ↗

Sex differences in epigenetic ageing for older people living with HIVSemantic proximity Read ↗

Epigenetic aging is a hallmark of HIV pathogenesis and phenotypic outcomes.Semantic proximity Read ↗

Acceleration of Age-Associated Methylation Patterns in HIV-1-Infected AdultsSemantic proximity Read ↗

DNA methylation‐based telomere length is associated with HIV infection, physical frailty, cancer, and all‐cause mortalitySemantic proximity Read ↗

Increased Rate of Epigenetic Aging in Men Living With HIV Prior to TreatmentSemantic proximity Read ↗

Abrupt and altered cell-type specific DNA methylation profiles in blood during acute HIV infection persists despite prompt initiation of ARTSemantic proximity Read ↗

Decreased but persistent epigenetic age acceleration is associated with changes in T-cell subsets after initiation of highly active antiretroviral therapy in persons living with HIVSemantic proximity Read ↗

The Effects of Anti-retroviral Therapy on Epigenetic Age Acceleration Observed in HIV-1-infected AdultsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.