Article

Large-scale single-cell long-read genomics enables high-resolution microbiome profiling

2025-10-21

Abstract excerpt

<title>Abstract</title> <p>Microbial communities are extraordinarily diverse and play crucial roles in health and disease, yet current methods lack the resolution and scalability needed to dissect their genomic and ecological complexity at the single-cell level. Here, we present CAP-seq, a high-throughput single-microbe genomics platform that combines hydrogel-based semi-permeable encapsulation with moderate micr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8d0e3bd2-a350-5df2-bd0f-1d80b1d7d03e
DOI: 10.21203/rs.3.rs-7858644/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Large-scale single-cell long-read genomics enables high-resolution microbiome profilingDOI 10.21203/rs.3.rs-7858644/v1Read

Large-scale single-cell long-read genomics enables high-resolution microbiome profilingSemantic proximity Read

Massively parallel single-cell sequencing of genetic loci in diverse microbial populationsSemantic proximity Read

Obtaining high-quality draft genomes from uncultured microbes by cleaning and co-assembly of single-cell amplified genomes.Semantic proximity Read

<i>Microbe-seq</i> : high-throughput, single-microbe genomics with strain resolution, applied to a human gut microbiomeSemantic proximity Read

High-throughput generic single-entity sequencing using droplet microfluidicsSemantic proximity Read

Revealing within-species diversity in uncultured human gut bacteria with single-cell long-read sequencingSemantic proximity Read

Droplet-based single cell RNA sequencing of bacteria identifies known and previously unseen cellular statesSemantic proximity Read

Agarose Gel Microcapsules Enable Easy-to-prepare, Picolitre-scale Single-cell Genomics, Yielding Near-complete Genome SequencesSemantic proximity Read

Scalable single-cell metagenomic analysis with Bascet and ZornSemantic proximity Read

Capsule-Based Single-Cell Genome SequencingSemantic proximity Read

ACCIO: An Assembly-Based Tool Enabling Plasmid DetectionSemantic proximity Read

Droplet-based single cell RNA sequencing of bacteria identifies known and previously unseen cellular statesSemantic proximity Read