Article

Mutations in <i>VPS18</i> lead to a neutrophil maturation defect associated with disturbed vesicle homeostasis

2025-08-21

Abstract excerpt

Neutrophils, the first cells to arrive at the site of inflammation, are rather short-lived cells and thus have to be constantly replenished. During neutrophil development, vesicle dynamics need to be fine-tuned and impaired vesicle trafficking has been linked to failure in neutrophil maturation. Here, we characterized the role of VPS18 as a central core component of CORVET & HOPS tethering complexes for neutrophil...

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Literature Corpus work: 8d09d9ae-a5d3-5d40-9467-aea562ce94f0
DOI: 10.1101/2025.08.15.670286

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