Mutations in VPS18 lead to a neutrophil maturation defect associated with disturbed vesicle homeostasis.

doi:10.1038/s41419-025-08338-w

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Article

Mutations in VPS18 lead to a neutrophil maturation defect associated with disturbed vesicle homeostasis.

Cell death & disease - 12 Jan 2026

Gao Jincheng, Bader Almke, Linder Monika I, Cheng Jingyuan, Richter Mathis, da Costa Raul, Zehrer Annette, Mitt Karl, Popper Bastian, Meissner Felix, Wei Xiang, de Vega Gómez Enrique, Tatematsu Megumi, Rohlfs Meino, Frenz-Wiessner Stephanie, Kiziltug Mehmet, Somekh Ido, Yacobovich Joanne, Steinberg-Shemer Orna, Somech Raz, Soehnlein Oliver, Schmid Bettina, Klein Christoph, Walzog Barbara, Maier-Begandt Daniela

Abstract excerpt

Neutrophils, the first cells to arrive at the site of inflammation, are rather short-lived cells and thus have to be constantly replenished. During neutrophil development, vesicle dynamics need to be fine-tuned and impaired vesicle trafficking has been linked to failure in neutrophil maturation. Here, we characterized the role of VPS18 as a central core component of CORVET & HOPS tethering complexes for...

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Identifiers

PMID: 41526335
DOI: 10.1038/s41419-025-08338-w
PMCID: PMC12876832

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VPS18

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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Mutations in VPS18 lead to a neutrophil maturation defect associated with disturbed vesicle homeostasis.PMID 41526335Read ↗

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