Article

Utility of the second-generation curcumin analogue RL71 in canine histiocytic sarcoma

2023-07-24

Abstract excerpt

Canine histiocytic sarcoma is an aggressive cancer, with a high rate of metastasis. Thus, novel therapeutic approaches are needed. Synthetic analogues of curcumin have elicited potent anti-cancer activity in multiple in vitro and in vivo models of human cancer. Furthermore, the compound 3,5-bis(3,4,5-trimethoxybenzylidene)-1-methylpiperidine-4-one (RL71) has recently exhibited potent cell cycle arrest and apoptoti...

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Literature Corpus work: 8cf11f80-384a-5847-95c9-b010ff19387b
DOI: 10.21203/rs.3.rs-3183580/v1

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