Article
In vitro anticancer effects of alpelisib against PIK3CA‑mutated canine hemangiosarcoma cell lines.
Oncology reports - 1 Apr 2022
Maeda Marika, Ochiai Kazuhiko, Michishita Masaki, Morimatsu Masami, Sakai Hiroki, Kinoshita Nayuta, Sakaue Motoharu, Onozawa Eri, Azakami Daigo, Yamamoto Masami, Ishioka Katsumi, Sadahira Takuya, Watanabe Masami, Tanaka Yoshikazu
Abstract excerpt
Hemangiosarcoma (HSA) is a malignant neoplasm that occurs in humans and canines with a poor prognosis owing to metastatic spread, despite effective treatment. The frequency of spontaneous HSA development is higher in canines than in humans. Therefore, canine HSA is a useful model of intractable human disease, which requires early detection and an effective therapeutic strategy. A high frequency of the p110α...
Topics
- Animals
- Cell Line, Tumor
- Class I Phosphatidylinositol 3-Kinases
- Dogs
- HeLa Cells
- Hemangiosarcoma
- Humans
- Mutation
- Thiazoles