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Selective Targeting of Regulated Rhabdomyosarcoma Cells by Trinuclear Ruthenium(II)–Arene Complexes

3 Apr 2024

Abstract excerpt

High Resolution Image Download MS PowerPoint Slide The use of benzimidazole-based trinuclear ruthenium(II)–arene complexes ( 1 – 3 ) to selectively target the rare cancer rhabdomyosarcoma is reported. Preliminary cytotoxic evaluations of the ruthenium complexes in an eight-cancer cell line panel revealed enhanced, selective cytotoxicity toward rhabdomyosarcoma cells (RMS). The trinuclear complex 1 was noted to...

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PMID: 38569098
DOI: 10.1021/acs.jmedchem.4c00256

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