Back to search

Article

Calreticulin co-expression supports high level production of a recombinant SARS-CoV-2 spike mimetic in <i>Nicotiana benthamiana</i>

2020-06-14

Abstract excerpt

An effective prophylactic vaccine is urgently needed to protect against SARS-CoV-2 infection. The viral spike, which mediates entry into cells by interacting with the host angiotensin-converting enzyme 2, is the primary target of most vaccines in development. These vaccines aim to elicit protective immunity against the glycoprotein by use of inactivated virus, vector-mediated delivery of the antigen in vivo , or...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
8c0d4e2a-8695-547d-b651-f1f96ee450bc
DOI
10.1101/2020.06.14.150458
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Calreticulin co-expression supports high level production of a recombinant SARS-CoV-2 spike mimetic in <i>Nicotiana benthamiana</i>DOI 10.1101/2020.06.14.150458
Transient production of Receptor-Binding Domain of SARS-CoV-2 in Nicotiana benthamiana plants induces specific antibodies in immunized miceSemantic proximity
Plant-produced SARS-CoV-2 receptor binding domain (RBD) variants showed differential binding efficiency with anti-spike specific monoclonal antibodiesSemantic proximity
High-level expression of the monomeric SARS-CoV-2 S protein RBD 320-537 in stably transfected CHO cells by the <i>EEF1A1</i> -based plasmid vectorSemantic proximity
Expression of a constitutively active nitrate reductase increases SARS-CoV-2 Spike protein production in <i>Nicotiana benthamiana</i> leaves that otherwise show traits of senescenceSemantic proximity
Rapid, high-yield production of full-length SARS-CoV-2 spike ectodomain by transient gene expression in CHO cellsSemantic proximity
Engineering and expression of a human rotavirus candidate vaccine in Nicotiana benthamiana.Semantic proximity
Plant‐made dengue virus‐like particles produced by co‐expression of structural and non‐structural proteins induce a humoral immune response in miceSemantic proximity
Efficient expression in the prokaryotic host system, purification and structural analyses of the recombinant human ACE2 catalytic subunit as a hybrid protein with the B subunit of cholera toxin (CTB-ACE2)Semantic proximity
Practical Use of Tobravirus-Based Vector to Produce SARS-CoV-2 Antigens in PlantsSemantic proximity
Molecular changes in agroinfiltrated leaves of <i>Nicotiana benthamiana</i> expressing suppressor of silencing P19 and coronavirus-like particlesSemantic proximity
Precision Glycoform Engineering: Combining plant and <i>in vitro</i> systems for tailored biopharmaceutical productionSemantic proximity
Cell-free glycoengineering of the recombinant SARS-CoV-2 spike glycoproteinSemantic proximity
Select a neighboring publication to make it the new centre.