Article

Genomic and molecular evidence that the lncRNA<i>DSP-AS1</i>modulates Desmoplakin expression

2025-03-31

Abstract excerpt

Cardiac desmosomes are specialized cell junctions responsible for cardiomyocytes mechanical coupling. Mutation in desmosomal genes cause autosomal dominant and recessive familial arrhythmogenic cardiomyopathy. Motivated by evidence that Mendelian diseases share genetic architecture with common complex traits, we assessed whether common variants in any desmosomal gene were associated with cardiac conduction traits...

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Literature Corpus work: 8bf7d59a-8ea6-5ab4-aa1f-0299aee0d9fc
DOI: 10.1101/2025.03.29.25324867

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