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Article

Desmoplakin and clinical manifestations of desmoplakin cardiomyopathy

2 Aug 2021

Abstract excerpt

ABSTRACT: Desmoplakin (DSP), encoded by the DSP gene, is the main desmosome component and is abundant in the myocardial tissue. There are three DSP isoforms that assume the role of supporting structural stability through intercellular adhesion. It has been found that DSP regulates the transcription of adipogenic and fibrogenic genes, and maintains appropriate electrical conductivity by regulating gap junctions...

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PMID: 34343150
DOI: 10.1097/cm9.0000000000001581

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