Article

Understanding the role of HACD enzymes and very long chain fatty acids in muscle development and disease

2019-01-01

Abstract excerpt

3-hydroxyacyl-coA dehydratase (HACD) enzymes form part of a complex that elongates fatty acids with very long carbon chain length (VLCFA) (>20C). There are four paralogous HACD enzymes in mammals (encoded by HACD1-4), each with a distinct tissue distribution: HACD1 is specifically expressed in striated muscles and mutations in HACD1 cause congenital myopathies in humans, dogs and mice. The canine autosomal recessi...

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Literature Corpus work: 8be726aa-69ce-53a8-b1ab-df2d04cb6fb6
DOI: 10.17638/03057583

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