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Article

<i>HACD1</i>, a regulator of membrane composition and fluidity, promotes myoblast fusion and skeletal muscle growth

9 Jul 2015

Abstract excerpt

The reduced diameter of skeletal myofibres is a hallmark of several congenital myopathies, yet the underlying cellular and molecular mechanisms remain elusive. In this study, we investigate the role of HACD1/PTPLA, which is involved in the elongation of the very long chain fatty acids, in muscle fibre formation. In humans and dogs, HACD1 deficiency leads to a congenital myopathy with fibre size disproportion...

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PMID: 26160855
DOI: 10.1093/jmcb/mjv049

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