Article

Single-cell and spatial transcriptomics of vulvar lichen sclerosus reveal multi-compartmental alterations in gene expression and signaling cross-talk

2024-08-17

Abstract excerpt

<h4>ABSTRACT</h4> Vulvar diseases are a critical yet often neglected area of women’s health, profoundly affecting patients’ quality of life and frequently resulting in long-term physical and psychological challenges. Lichen sclerosus (LS) is a chronic inflammatory skin disorder that predominantly affects the vulva, leading to severe itching, pain, scarring, and an increased risk of malignancy. Despite its profoun...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8bbc15c7-12aa-506d-901f-8098a39a1aaf
DOI: 10.1101/2024.08.14.607986

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell and spatial transcriptomics of vulvar lichen sclerosus reveal multi-compartmental alterations in gene expression and signaling cross-talkDOI 10.1101/2024.08.14.607986Read

Spatial and Single-Cell Transcriptomics Reveal Keratinocytes as Key Players in Vulvar Lichen Sclerosus PathogenesisSemantic proximity Read

Multi-omics analysis unveiled fibroblast-mediated pathogenesis in male genital lichen sclerosusSemantic proximity Read

Transcriptome Profiling and Network Analysis Provide Insights Into the Pathogenesis of Vulvar Lichen SclerosusSemantic proximity Read

Single-cell sequencing combined with spatial transcriptomics reveals the characteristics of follicle-targeted inflammation patterns in primary cicatricial alopeciaSemantic proximity Read

A Transcriptomic Atlas of Healthy Human Skin Links Regional Identity to Inflammatory DiseaseSemantic proximity Read

Immune Dysregulation and Cellular Composition in Lichen Sclerosus Revealed by Integrative Epigenetic Analysis with Cell Type DeconvolutionSemantic proximity Read

A comparative study of genital lichen sclerosus transcriptomesSemantic proximity Read

Single-cell transcriptomics in dermatologySemantic proximity Read

Development of an Integrated Single-Cell and Spatial Transcriptomics Atlas of Healthy Human Skin Focusing on the Pilosebaceous UnitSemantic proximity Read

The Use of Single-Cell RNA-Sequencing and Spatial Transcriptomics in Understanding the Pathogenesis and Treatment of Skin DiseasesSemantic proximity Read

A Targeted Spatial Transcriptomics Framework for a High-Resolution Human Skin Cell AtlasSemantic proximity Read

Lichen Sclerosus: An autoimmunopathogenic and genomic enigma with emerging genetic and immune targetsSemantic proximity Read