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Article

Impairment of SLC17A8 encoding vesicular glutamate transporter-3, VGLUT3, underlies nonsyndromic deafness DFNA25 and inner hair cell dysfunction in null mice.

American journal of human genetics - 1 Aug 2008

Ruel Jérôme, Emery Sarah, Nouvian Régis, Bersot Tiphaine, Amilhon Bénédicte, Van Rybroek Jana M, Rebillard Guy, Lenoir Marc, Eybalin Michel, Delprat Benjamin, Sivakumaran Theru A, Giros Bruno, El Mestikawy Salah, Moser Tobias, Smith Richard J H, Lesperance Marci M, Puel Jean-Luc

Abstract excerpt

Autosomal-dominant sensorineural hearing loss is genetically heterogeneous, with a phenotype closely resembling presbycusis, the most common sensory defect associated with aging in humans. We have identified SLC17A8, which encodes the vesicular glutamate transporter-3 (VGLUT3), as the gene respon...

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Identifiers

PMID: 18674745
DOI: 10.1016/j.ajhg.2008.07.008
PMCID: PMC2495073

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18674745-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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