miR-431 secreted by human vestibular schwannomas increases the mammalian inner ear’s vulnerability to noise trauma

Abstract excerpt

Introduction: Vestibular schwannoma (VS) is an intracranial tumor that arises on the vestibular branch of cranial nerve VIII and typically presents with sensorineural hearing loss (SNHL). The mechanisms of this SNHL are postulated to involve alterations in the inner ear's microenvironment mediated by the genetic cargo of VS-secreted extracellular vesicles (EVs). We aimed to identify the EV cargo associated with...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Hearing, Cochlea, Tinnitus, Genetics
• Share to Meningioma and schwannoma management
• Share to Vestibular and auditory disorders