Article

Regulation of sleep quantity and intensity by long and short isoforms of SLEEPY kinase

2022-07-15

Abstract excerpt

In Sleepy ( Sik3 Slp ) or Sik3 S551A mice, deletion or mutation of inhibitory phosphorylation site serine 551 (S551) from salt-inducible kinase 3 (SIK3) markedly increases daily non-rapid eye movement sleep (NREMS) amount, accompanied with constitutively elevated NREMS delta power density–a measure of sleep intensity or quality. Multiple SLP/SIK3 isoforms are expressed in mouse brain neurons, however, their re...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8b750bfc-a6d4-55d4-871c-e8e81d2b800e
DOI: 10.1101/2022.07.14.500024

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Regulation of sleep quantity and intensity by long and short isoforms of SLEEPY kinaseDOI 10.1101/2022.07.14.500024Read

Induction of Mutant Sik3Sleepy Allele in Neurons in Late Infancy Increases Sleep Need.Semantic proximity Read

Somatic genetics analysis of sleep in adult miceSemantic proximity Read

Forward-genetics analysis of sleep in randomly mutagenized mice.Semantic proximity Read

A phosphorylation-deficient mutant of Sik3, a homolog of Sleepy, alters circadian sleep regulation by PDF neurons in DrosophilaSemantic proximity Read

Shank3 influences mammalian sleep developmentSemantic proximity Read

The circadian clock gene Csnk1e regulates rapid eye movement sleep amount, and nonrapid eye movement sleep architecture in mice.Semantic proximity Read

Sleep alterations in a mouse model of Spinocerebellar ataxia type 3Semantic proximity Read

SIK3-HDAC4 in the suprachiasmatic nucleus regulates the timing of arousal at the dark onset and circadian period in mice.Semantic proximity Read

Sex differences in sleep deficits in mice with an autism-linked Shank3 mutation.Semantic proximity Read

NPAS2 as a transcriptional regulator of non-rapid eye movement sleep: genotype and sex interactions.Semantic proximity Read

Drosophila Hyperkinetic mutants have reduced sleep and impaired memory.Semantic proximity Read

Elevated Delta Power in a Maternal <i>UBE3A</i> -Deletion Pig Model of Angelman SyndromeSemantic proximity Read