Article

<i>RRM2B</i> is frequently amplified across multiple tumor types: non-oncogenic addiction and therapeutic opportunities

2020-09-11

Abstract excerpt

RRM2B plays a crucial role in DNA replication, repair and oxidative stress. While germline RRM2B mutations have been implicated in mitochondrial disorders, its relevance to cancer has not been established. Here, using TCGA data, we investigated RRM2B alterations in cancer. We found that RRM2B is highly amplified in multiple tumor types, particularly in MYC -amplified tumors, and is associated with increased R...

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Literature Corpus work: 8b2a5926-833d-5054-a1a5-efd22185ffd7
DOI: 10.1101/2020.09.10.291567

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