Article

Smooth Muscle Cell Death Drives an Osteochondrogenic Phenotype and Severe Proximal Vascular Disease in Progeria

2023-01-11

Abstract excerpt

<h4>ABSTRACT</h4> Hutchinson-Gilford Progeria Syndrome results in rapid aging and severe cardiovascular sequelae that accelerate near end of life. We associate progressive deterioration of arterial structure and function with single cell transcriptional changes, which reveals a rapid disease process in proximal elastic arteries that largely spares distal muscular arteries. These data suggest a novel sequence of p...

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Literature Corpus work: 7b9e164d-1954-58d8-b053-78aa8e6bbbc0
DOI: 10.1101/2023.01.10.523266

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