Article

Intervention for Critical Aortic Stenosis in Hutchinson-Gilford Progeria Syndrome

2023-10-06

Abstract excerpt

<title>Abstract</title> <p>Background Hutchinson-Gilford Progeria Syndrome (HGPS) is an ultra-rare genetic premature aging disease that is historically fatal in teenage years, secondary to severe accelerated atherosclerosis. The only approved treatment is the farnesyltransferase inhibitor lonafarnib, which improves vascular structure and function, extending lifespan by several years. With this longer lifespan, c...

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Literature Corpus work: f82eb67c-f8e2-5487-8044-8e669143ca2e
DOI: 10.21203/rs.3.rs-3414391/v1

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