Article

Prevalent glutamyl-endopeptidases in the commensal skin microbiome have itch-relevant activity

2026-07-20

Abstract excerpt

Atopic dermatitis (AD) is frequently accompanied by pruritus, which has predominantly been attributed to skin colonization by Staphylococcus aureus , particularly through cleavage of protease-activated receptor 1 (PAR1) by the glutamyl endopeptidase (GEP) V8 protease. Whether related GEPs from other skin-associated staphylococci contribute to this process remains unclear. Here, we analyzed 273 staphylococcal isol...

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Literature Corpus work: f693c4d9-c38b-575c-9abf-e5a4ef38cd49
DOI: 10.64898/2026.07.17.739094

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