Article

Massively parallel profiling of HIV-1 resistance to the fusion inhibitor enfuvirtide

2018-11-19

Abstract excerpt

Resistance to enfuvirtide, the only clinically approved HIV-1 entry inhibitor, has primarily been mapped to the binding site in the N-terminal heptad repeat (NHR) of the Env transmembrane domain and a limited number of allosteric sites. To better delineate the genotypic determinants of resistance, we used deep mutational scanning to quantify how all mutations to HIV-1 Env affect enfuvirtide sensitivity. We identif...

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Literature Corpus work: 8a6d4ec2-e9f9-5047-bedd-896d4ef1c64b
DOI: 10.1101/472746

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