Article

Integrative analysis of mRNA stability regulation uncovers a metastasis-suppressive program in breast cancer

2025-06-07

Abstract excerpt

Heterogeneity in cancer gene expression is typically linked to genetic and epigenetic alterations, yet post-transcriptional regulation likely influences these patterns as well. However, the quantitative contribution of post-transcriptional mechanisms to cancer transcriptome dynamics remains unclear. Here, we systematically measured mRNA dynamics across diverse breast cancer models, revealing that mRNA stability si...

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Literature Corpus work: 8a4bfd10-32d0-5788-ad41-96c6e9d2c13a
DOI: 10.1101/2025.06.06.658309

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