Article

Bacterial defiance as a form of prodrug failure

2019-02-21

Abstract excerpt

<h4>ABSTRACT</h4> Classifying the mechanisms of antibiotic failure has led to the development of new treatment strategies for killing bacteria. Among the currently described mechanisms, which include resistance, persistence and tolerance, we propose bacterial defiance as a form of antibiotic failure specific to prodrugs. As a prototypic model of a bacteria-activated prodrug, we construct cationic antimicrobial p...

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Literature Corpus work: 89f46e21-901e-5d67-a891-5302bd40c20f
DOI: 10.1101/556951

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