Article
Dual origin of relapses in retinoic-acid resistant acute promyelocytic leukemia.
Nature communications - 24 May 2018
Lehmann-Che Jacqueline, Bally Cécile, Letouzé Eric, Berthier Caroline, Yuan Hao, Jollivet Florence, Ades Lionel, Cassinat Bruno, Hirsch Pierre, Pigneux Arnaud, Mozziconacci Marie-Joelle, Kogan Scott, Fenaux Pierre, de Thé Hugues
Abstract excerpt
Retinoic acid (RA) and arsenic target the t(15;17)(q24;q21) PML/RARA driver of acute promyelocytic leukemia (APL), their combination now curing over 95% patients. We report exome sequencing of 64 matched samples collected from patients at initial diagnosis, during remission, and following relapse after historical combined RA-chemotherapy treatments. A first subgroup presents a high incidence of additional...
Topics
- 5'-Nucleotidase
- Animals
- Antineoplastic Agents
- Arsenic Trioxide
- Drug Resistance, Neoplasm
- Humans
- Leukemia, Promyelocytic, Acute
- Male
- Mice
- Mutation