Article

Crystallographic characterisation and development of bi-substrate inhibitors of coronavirus nsp14 methyltransferase

2025-10-01

Abstract excerpt

SARS-CoV-2 non-structural protein 14 (nsp14) is essential for viral mRNA cap guanine-N7 methylation and represents a promising but underexplored antiviral target. Herein we describe a structure-guided campaign based on a hit from a focussed SAM mimetic library. Systematic SAR exploration guided by six X-ray co-crystal structures in complex with SARS-CoV-2 led to compound 26 , a bi-substrate inhibitor that bridges...

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Literature Corpus work: 89d6e4e5-912b-5d1b-9423-e874e8022ac5
DOI: 10.1101/2025.09.30.679521

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