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Assay development and screening of inhibitors targeting the SARS-CoV-2 2′-O-methyltransferase NSP16

21 May 2025

Abstract excerpt

The coronavirus disease-2019 (COVID-19) pandemic, etiologically caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has profoundly impacted the global health. While vaccines have been developed, they have shown limited efficacy in treating patients already under infection or preventing infection with emerging SARS-CoV-2 variants. The nonstructural protein 16 (NSP16), with the assistance of the...

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PMID: 41550643
DOI: 10.1016/j.pscia.2025.100076

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