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Article

Crystal structure and functional analysis of the SARS-coronavirus RNA cap 2'-O-methyltransferase nsp10/nsp16 complex.

PLoS pathogens - 1 May 2011

Decroly Etienne, Debarnot Claire, Ferron François, Bouvet Mickael, Coutard Bruno, Imbert Isabelle, Gluais Laure, Papageorgiou Nicolas, Sharff Andrew, Bricogne Gérard, Ortiz-Lombardia Miguel, Lescar Julien, Canard Bruno

Abstract excerpt

Cellular and viral S-adenosylmethionine-dependent methyltransferases are involved in many regulated processes such as metabolism, detoxification, signal transduction, chromatin remodeling, nucleic acid processing, and mRNA capping. The Severe Acute Respiratory Syndrome coronavirus nsp16 protein is a S-adenosylmethionine-dependent (nucleoside-2'-O)-methyltransferase only active in the presence of its activating...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 21637813
DOI: 10.1371/journal.ppat.1002059
PMCID: PMC3102710

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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