Article

Stromal signals dominate gene expression signature scores that aim to describe cancer-intrinsic stemness or mesenchymality characteristics

2023-08-27

Abstract excerpt

<h4>Purpose</h4> Epithelial-to-mesenchymal transition (EMT) in cancer cells confers migratory ability, a crucial aspect of tumor metastasis that frequently leads to death. In multiple studies, authors proposed gene expression signatures for EMT, stemness, and mesenchymality (EMT-related) characteristics of tumors based on bulk tumor expression profiling. However, recent studies have suggested that non-cancerous c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 89957a0b-a3e8-5b97-bee9-7d9eeb2342d8
DOI: 10.1101/2023.08.25.554747

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Stromal signals dominate gene expression signature scores that aim to describe cancer-intrinsic stemness or mesenchymality characteristicsDOI 10.1101/2023.08.25.554747Read

Stromal Signals Dominate Gene Expression Signature Scores That Aim to Describe Cancer Cell–intrinsic Stemness or Mesenchymality CharacteristicsSemantic proximity Read

Decoupling epithelial-mesenchymal transitions from stromal profiles by integrative expression analysisSemantic proximity Read

Cancer-associated fibroblasts are the main contributors to epithelial-to-mesenchymal signatures in the tumor microenvironmentSemantic proximity Read

Deciphering the Dynamics of Epithelial-Mesenchymal Transition and Cancer Stem Cells in Tumor ProgressionSemantic proximity Read

Concise Review: Stem Cells and Epithelial-Mesenchymal Transition in Cancer: Biological Implications and Therapeutic TargetsSemantic proximity Read

Quantifying Cancer Epithelial-Mesenchymal Plasticity and Its Association with Stemness and Immune ResponseSemantic proximity Read

Quantifying Cancer Epithelial-Mesenchymal Plasticity and its Association with Stemness and Immune ResponseSemantic proximity Read

Cancer stemness, intratumoral heterogeneity, and immune response across cancersSemantic proximity Read

Cancer-associated fibroblasts as abettors of tumor progression at the crossroads of EMT and therapy resistanceSemantic proximity Read

Characterization of stem cell landscape and identification of stemness-relevant prognostic gene signature to aid immunotherapy in colorectal cancerSemantic proximity Read

Cancer-Associated Stemness and Epithelial-to-Mesenchymal Transition Signatures Related to Breast Invasive Carcinoma PrognosticSemantic proximity Read

Epithelial mesenchymal transition traits in human breast cancer cell lines parallel the CD44(hi/)CD24 (lo/-) stem cell phenotype in human breast cancer.Semantic proximity Read