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Immune Checkpoint Molecules as Biomarkers of Staphylococcus aureus Bone Infection and Clinical Outcome

2024-12-31

Abstract excerpt

Staphylococcus aureus prosthetic joint infections (PJIs) are broadly considered incurable, and clinical diagnostics that guide conservative vs. aggressive surgical treatments do not exist. Multi-omics studies in a humanized NSG-SGM3 BLT mouse model demonstrate human T cells: 1) are remarkably heterogenous in gene expression and numbers, and 2) exist as a mixed population of activated, progenitor-exhausted, and ter...

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Literature Corpus work
897ea4d9-ccdc-55ef-9ea6-b823e1fcaf97
DOI
10.1101/2024.12.30.630837
Open publication

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Immune Checkpoint Molecules as Biomarkers of Staphylococcus aureus Bone Infection and Clinical OutcomeDOI 10.1101/2024.12.30.630837
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