Article

Expanded Multiplexing on Sensor-Constrained Microfluidic Partitioning Systems

2022-12-23

Abstract excerpt

Microfluidics can split samples into thousands or millions of partitions such as droplets or nanowells. Partitions capture analytes according to a Poisson distribution, and in diagnostics, the analyte concentration is commonly calculated with a closed-form solution via maximum likelihood estimation (MLE). Here, we present a generalization of MLE with microfluidics, an extension of our previously developed Sparse P...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 89446f57-1a0b-5c64-bf1b-07e6dd0063ce
DOI: 10.1101/2022.12.23.521805

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Expanded Multiplexing on Sensor-Constrained Microfluidic Partitioning SystemsDOI 10.1101/2022.12.23.521805Read

Robust Multichannel Encoding for Highly Multiplexed Quantitative PCRSemantic proximity Read

Digital Assays Part I: Partitioning Statistics and Digital PCR.Semantic proximity Read

Droplet barcoding for massively parallel single-molecule deep sequencing.Semantic proximity Read

AM‑DMF-Lib-prep: A clinical ready lib-prep-on-a-chip platform with active-matrix digital microfluidicsSemantic proximity Read

All-in-One Microfluidic Chip for the Point-of-Care-Testing of Nucleic Acids: Combining a Dynamic-Seal Microvalve, Ultrasound-Assisted Reaction Chamber, and Slice Amplification with a Fluorescence Detection SystemSemantic proximity Read

Accurate bulk quantitation of droplet digital PCRSemantic proximity Read

A programmable droplet-based microfluidic device applied to multiparameter analysis of single microbes and microbial communities.Semantic proximity Read

Application of under-oil open microfluidic systems for rapid phenotypic antimicrobial susceptibility testingSemantic proximity Read

Virtual partition digital PCR for high precision chromosomal counting applicationsSemantic proximity Read

Self-Interference Digital Optofluidic Genotyping for Integrated and Automated Label-Free Pathogen Detection.Semantic proximity Read

High-throughput automated microfluidic sample preparation for accurate microbial genomics.Semantic proximity Read

Integrated Microfluidic Sample-to-Answer System for Direct Nucleic Acid-Based Detection of Group B Streptococci in Clinical Vaginal/Anal Swab SamplesSemantic proximity Read