Article
High-throughput automated microfluidic sample preparation for accurate microbial genomics.
Nature communications - 27 Jan 2017
Kim Soohong, De Jonghe Joachim, Kulesa Anthony B, Feldman David, Vatanen Tommi, Bhattacharyya Roby P, Berdy Brittany, Gomez James, Nolan Jill, Epstein Slava, Blainey Paul C
Abstract excerpt
Low-cost shotgun DNA sequencing is transforming the microbial sciences. Sequencing instruments are so effective that sample preparation is now the key limiting factor. Here, we introduce a microfluidic sample preparation platform that integrates the key steps in cells to sequence library sample preparation for up to 96 samples and reduces DNA input requirements 100-fold while maintaining or improving data...
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