Article

Mouse model and human patient data suggest critical roles for Pten and p53 in suppressing POLE mutant tumor development

2021-10-12

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in the exonuclease domain of POLE are associated with tumors harboring very high mutation burdens. The mechanisms linking this significant mutation accumulation and tumor development remain poorly understood. Pole +/P286R ; Trp53 +/− mice showed accelerated cancer mortality compared to Pole +/P286R ; Trp53 +/+ mice. Cells from Pole +/P286R mice showed increased p53 activation, an...

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Literature Corpus work: 893cb293-2af1-51e6-b3d2-e4229916b29d
DOI: 10.1101/2021.10.10.463847

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