Article
Molecular profiling and sequential somatic mutation shift in hypermutator tumours harbouring POLE mutations.
Scientific reports - 7 Jun 2018
Hatakeyama Keiichi, Ohshima Keiichi, Nagashima Takeshi, Ohnami Shumpei, Ohnami Sumiko, Serizawa Masakuni, Shimoda Yuji, Maruyama Koji, Akiyama Yasuto, Urakami Kenichi, Kusuhara Masatoshi, Mochizuki Tohru, Yamaguchi Ken
Abstract excerpt
Defective DNA polymerase ε (POLE) proofreading leads to extensive somatic mutations that exhibit biased mutational properties; however, the characteristics of POLE-mutated tumours remain unclear. In the present study, we describe a molecular profile using whole exome sequencing based on the transition of somatic mutations in 10 POLE-mutated solid tumours that were obtained from 2,042 Japanese patients. The bias...
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