Article

Dysregulated Airway Host Defense in Hyper IgE Syndrome due to STAT3 Mutations

2024-08-15

Abstract excerpt

<h4>Rationale</h4> Hyper IgE syndrome (STAT3-HIES), also known as Job’s syndrome, is a rare immunodeficiency disease typically caused by dominant-negative STAT3 mutations. STAT3-HIES syndrome is characterized by chronic pulmonary infection and inflammation, suggesting impairment of pulmonary innate host defense. <h4>Objectives</h4> To identify airway epithelial host defense defects consequent to STAT3 mutations...

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Literature Corpus work: 892f7c02-722a-556d-a7e3-1ffc4c36a112
DOI: 10.1101/2024.08.14.607930

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