Article
STAT3 regulates NK and NKT cell differentiation through C-X3-C motif chemokine receptor 1 (CX3CR1) in hyper-IgE syndrome.
Molecular biomedicine - 10 Nov 2025
Liu Ju, Yang Jingzhi, Tang Jianing, Tang Hongxia, Dai Xin, Jin Peiyao, Huang Yanmei, Li Zhenzhen, Zhang Ziyin, Guo Xiaohuan, Bitzan Martin, Yin Xiaoling, Liu Chaohong
Abstract excerpt
Mutations in the signal transducer and activator of transcription 3 (STAT3) gene are strongly associated with Hyper-IgE Syndrome (HIES), a rare immunodeficiency disorder characterized by elevated levels of IgE and recurrent infections. The molecular mechanisms of how STAT3 dysfunction contributes to the pathophysiology of HIES are complex and not fully elucidated, especially in natural killer (NK) cells, which...
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