Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Combined Glycoprotein Mutations in Rabies Virus Promote Astrocyte Tropism and Protective CNS Immunity in Mice.

Viruses - 29 Jan 2026

Bertoune Mirjam Anna Rita, Kolbe Corinna, Werner Ann-Cathrin, Steinmetz Maren, Dietzschold Bernhard, Weihe Eberhard

Abstract excerpt

Rabies virus (RABV) causes fatal encephalitis once it invades the central nervous system (CNS), and treatment options are extremely limited at this stage. We investigated the recombinant RABV variants SPBN, SPBNGA (glycoprotein substitution R333E), SPBNGAK (R333E plus N194K), SPBNGAS (R333E plus N194S), and TriGAS (three copies of the R333E/N194S glycoprotein). We evaluated their cellular tropism and immune...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytes
Share to Central Nervous System

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Disease Models, Animal

Share to Glycoproteins

Share to Rabies

Share to Rabies virus

Share to Viral Tropism

Source

Open in PubMed Open full text

Identifiers

PMID: 41754524
DOI: 10.3390/v18020181
PMCID: PMC12944952

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Combined Glycoprotein Mutations in Rabies Virus Promote Astrocyte Tropism and Protective CNS Immunity in Mice.PMID 41754524Read ↗

Cell-type specific innate immune responses shape rabies virus tropismSemantic proximity Read ↗

Glu333 in rabies virus glycoprotein is involved in virus attenuation through astrocyte infection and interferon responsesSemantic proximity Read ↗

EXTRANEURAL RABIES VIRUS INFECTION LEADS TO TISSUE DAMAGE AND CELL DEATH IN MICESemantic proximity Read ↗

The roles of rabies virus structural proteins in immune evasion and implications for vaccine developmentSemantic proximity Read ↗

Human brain cell types shape host-rabies virus transcriptional interactions revealing a preexisting pro-viral astrocyte subpopulationSemantic proximity Read ↗

Postexposure Treatment with the Live-Attenuated Rabies Virus (RV) Vaccine TriGAS Triggers the Clearance of Wild-Type RV from the Central Nervous System (CNS) through the Rapid Induction of Genes Relevant to Adaptive Immunity in CNS TissuesSemantic proximity Read ↗

Human brain cell types shape host-rabies virus transcriptional interactions revealing a preexisting pro-viral astrocyte subpopulationSemantic proximity Read ↗

Spread and pathogenic characteristics of a G-deficient rabies virus recombinant: an in vitro and in vivo studySemantic proximity Read ↗

A spatial and cellular distribution of rabies virus infection in the mouse brain revealed by fMOST and single‐cell RNA sequencingSemantic proximity Read ↗

Research Advances on the Interactions between Rabies Virus Structural Proteins and Host Target Cells: Accrued Knowledge from the Application of Reverse Genetics SystemsSemantic proximity Read ↗

Pre- and post-exposure safety and efficacy of attenuated rabies virus vaccines are enhanced by their expression of IFNγ.Semantic proximity Read ↗

Expression of Interferon Gamma by a Recombinant Rabies Virus Strongly Attenuates the Pathogenicity of the Virus via Induction of Type I InterferonSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.