Human Gut Bacteria Convert Endogenous Steroids into Host Cortisol Shuttle Inhibitors

Abstract excerpt

11β-hydroxysteroid dehydrogenase 2 (HSD11B2) protects the mineralocorticoid receptor from glucocorticoid overstimulation by inactivating cortisol. HSD11B2 inhibition can drive receptor overactivation and contribute to hypertension; however, endogenous inhibitors remain poorly defined. Glycyrrhetinic acid-like factors (GALFs) are steroid-like metabolites that inhibit HSD11B2. Given the capacity of gut bacteria to m...

Topics

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• Adrenal Cortex Hormones
• Diet and metabolism studies
• Gene Expression Regulation
• Gut microbiota and health
• Hormonal Regulation and Hypertension
• Nutritional Studies and Diet
• Pharmacogenetics and Drug Metabolism
• Steroid Chemistry and Biochemistry

Identifiers and source

Literature Corpus work

891efc24-bd66-5cea-8944-707c2c7c16e3

DOI

10.64898/2026.08.21.746344