Article

Gut Bacteria Metabolize Natural and Synthetic Steroid Hormones via the Reductive OsrABC Pathway

2024-10-09

Abstract excerpt

Steroid hormone metabolism by the gut microbiome affects host physiology, but the underlying microbial pathways remain incompletely understood. Here, we isolate a novel human gut bacterium, Clostridium steroidoreducens T strain HCS.1 that reduces cortisol and related steroid hormones to 3β,5β-tetrahydrosteroid products. Through transcriptomics and enzymatic discovery, we establish the C. steroidoreducens OsrABC...

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Literature Corpus work: 790bff06-0b8a-5774-a6c3-c04be284e7d8
DOI: 10.1101/2024.10.08.617280

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