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Global transcriptional profiles of beating clusters derived from human induced pluripotent stem cells and embryonic stem cells are highly similar

15 Sept 2010

Abstract excerpt

BACKGROUND: Functional and molecular integrity of cardiomyocytes (CMs) derived from induced pluripotent stem (iPS) cells is essential for their use in tissue repair, disease modelling and drug screening. In this study we compared global transcriptomes of beating clusters (BCs) microdissected from differentiating human iPS cells and embryonic stem (ES) cells. RESULTS: Hierarchical clustering and principal...

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Share to Cardiac electrophysiology and arrhythmias
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PMID: 20843318
DOI: 10.1186/1471-213x-10-98

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