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Article

α-Phenylalanyl tRNA synthetase competes with Notch signaling through its N-terminal domain

2019-12-20

Abstract excerpt

The alpha subunit of the cytoplasmic Phenylalanyl tRNA synthetase (α-PheRS, FARSA in humans) displays cell growth and proliferation activities and its elevated levels can induce cell fate changes and tumor-like phenotypes that do neither dependent on the canonical function of charging tRNA Phe with phenylalanine nor on stimulating general translation. In intestinal stem cells of Drosophila midguts, α-PheRS level...

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Identifiers and source

Literature Corpus work
88c14d03-4e7c-54cf-8ffc-8905f1bbd98d
DOI
10.1101/2019.12.19.882530
Open publication

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α-Phenylalanyl tRNA synthetase competes with Notch signaling through its N-terminal domainDOI 10.1101/2019.12.19.882530
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