Article

A genome-wide meta-analysis of palmoplantar pustulosis implicates Th2 responses and cigarette smoking in disease pathogenesis

2024-01-17

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Palmoplantar pustulosis (PPP) is an inflammatory skin disorder that mostly affects smokers and manifests with painful pustular eruptions on the palms and soles. While the disease can present with concurrent plaque psoriasis, TNF and IL-17/IL-23 inhibitors show limited efficacy. There is therefore a pressing need to uncover PPP disease drivers and therapeutic targets. <h4>Objec...

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Literature Corpus work: 8885f246-198d-5f0a-ac23-bcbecf92f6a2
DOI: 10.1101/2024.01.17.24301406

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